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Journal: International Journal of Cancer. Journal International du Cancer
Article Title: Sickle cell trait is not associated with endemic Burkitt lymphoma: An ethnicity and malaria endemicity-matched case–control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer
doi: 10.1002/ijc.28378
Figure Lengend Snippet: Correlation between cellular and plasma EBV levels for healthy and eBL children. There was a significant correlation between cellular and plasma EBV levels in healthy Kenyan children from Nyanza (triangle) r = 0.177, p -value = 0.010. Children diagnosed with eBL had a nonsignificant correlation coefficient of r = 0.243, p -value = 0.05 (open circles). Based on the area under the ROC curve to assess sensitivity and specificity, dashed lines at 2-log EBV copies per microliter of plasma and 3-log EBV copies per microgram of human DNA were selected to visualize viral loads in healthy Kenyan children (triangle) and eBL patients (open circles) as a proposed threshold if either were used as a biomarker. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com .]
Article Snippet: Receiver operating characteristic (ROC) curves and putative thresholds for
Techniques: Clinical Proteomics, Biomarker Discovery